Holdgate, Geoffrey: search on Z-Library

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1

Anaphylaxis: Clinical patterns, mediator release, and severity

Brown, Simon G.A., Stone, Shelley F., Fatovich, Daniel M., Burrows, Sally A., Holdgate, Anna, Celenza, Antonio, Coulson, Adam, Hartnett, Leanne, Nagree, Yusuf, Cotterell, Claire, Isbister, Geoffrey K.

Journal:

Journal of Allergy and Clinical Immunology

Year:

2013

Language:

english

File:

PDF, 489 KB

english, 2013

2

Mechanistic enzymology in drug discovery: a fresh perspective

Holdgate, Geoffrey A., Meek, Thomas D., Grimley, Rachel L.

Journal:

Nature Reviews Drug Discovery

Year:

2017

File:

PDF, 52 KB

2017

3

Evaluation of the Use of Cold Plasma for Microtiter Plate Cleaning to Reduce Plastic Biohazard Waste

Plant, Helen, Hensley, Paul, Holdgate, Geoffrey, Jonsen, Paul, Wigglesworth, Mark

Journal:

SLAS Technology

Year:

2020

File:

PDF, 986 KB

2020

4

Detection of Drug Binding to a Target Protein Using EVV 2DIR Spectroscopy

Sowley, Hugh, Liu, Zhiqiang, Davies, Julia Ann, Peach, Robert Lucien, Guo, Rui, Sim, Sophie Anne, Long, Fengqin, Holdgate, Geoffrey Allan, Willison, Keith Robert, Zhuang, Wei, Klug, David R

Journal:

Journal of Physical Chemistry B

Year:

2019

File:

PDF, 886 KB

2019

5

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase

Klein, Tobias, Vajpai, Navratna, Phillips, Jonathan J., Davies, Gareth, Holdgate, Geoffrey A., Phillips, Chris, Tucker, Julie A., Norman, Richard A., Scott, Andrew D., Higazi, Daniel R., Lowe, David,

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 1.61 MB

english, 2015

6

Detection of Drug Binding to a Target Protein Using EVV 2DIR Spectroscopy

Sowley, Hugh, Liu, Zhiqiang, Davies, Julia Ann, Peach, Robert Lucien, Guo, Rui, Sim, Sophie Anne, Long, Fengqin, Holdgate, Geoffrey Allan, Willison, Keith Robert, Zhuang, Wei, Klug, David R

Journal:

Journal of Physical Chemistry B

Year:

2019

Language:

english

File:

PDF, 886 KB

english, 2019

7

Enzyme Kinetics and Binding Studies on Inhibitors of MEK Protein Kinase

VanScyoc, Wendy S., Holdgate, Geoffrey A., Sullivan, Jane E., Ward, Walter H. J.

Journal:

Year:

2008

Language:

english

File:

PDF, 496 KB

english, 2008

8

Potent and selective CK2 kinase inhibitors with effects on Wnt pathway signaling in vivo

Dowling, James E, Alimzhanov, Marat, Bao, Larry, Chuaqui, Claudio, Denz, Christopher, Jenkins, Emma L, Larsen, Nicholas, Lyne, Paul D, Pontz, Timothy, Ye, Qing, Holdgate, Geoffrey Allan, Snow, Lindsay

Journal:

ACS Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 1.94 MB

english, 2016

9

Prevention of MKK6-Dependent Activation by Binding to p38α MAP Kinase ‡

Sullivan, Jane E., Holdgate, Geoffrey A., Campbell, Douglas, Timms, David, Gerhardt, Stefan, Breed, Jason, Breeze, Alexander L., Bermingham, Alun, Pauptit, Richard A., Norman, Richard A., Embrey, Kevi

Journal:

Year:

2005

Language:

english

File:

PDF, 613 KB

english, 2005

10

Discovery and Characterization of MAPK-activated Protein Kinase-2 Prevention of Activation Inhibitors

Cumming, John G., Debreczeni, Judit É., Edfeldt, Fredrik, Evertsson, Emma, Harrison, Martin, Holdgate, Geoffrey A., James, Michael J., Lamont, Scott G., Oldham, Keith, Sullivan, Jane E., Wells, Stuart

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 4.52 MB

english, 2015

11

Inhibition of squalene synthase of rat liver by novel 3′ substituted quinuclidines

Fergus McTaggart, George R. Brown, Robert G. Davidson, Susan Freeman, Geoffrey A. Holdgate, Keith B. Mallion, Donald J. Mirrlees, Graham J. Smith, Walter H.J. Ward

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.32 MB

english, 1996

12

Activated Charcoal Decreases the Risk of QT Prolongation After Citalopram Overdose

Geoffrey K. Isbister, Lena E. Friberg, Barrie Stokes, Nicholas A. Buckley, Christopher Lee, Naren Gunja, Simon G. Brown, Ellen MacDonald, Andis Graudins, Anna Holdgate, Stephen B. Duffull

Journal:

Annals of Emergency Medicine

Year:

2007

Language:

english

File:

PDF, 9.87 MB

english, 2007

13

Inhibition of squalene synthase in vitro by 3-(biphenyl-4-yl)-quinuclidine

Walter H.J. Ward, Geoffrey A. Holdgate, Susan Freeman, Fergus McTaggart, Pauline A. Girdwood, Robert G. Davidson, Keith B. Mallion, George R. Brown, M.Allan Eakin

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.48 MB

english, 1996

14

Epidermal growth factor receptor tyrosine kinase: Investigation of catalytic mechanism, structure-based searching and discovery of a potent inhibitor

Walter H.J. Ward, Peter N. Cook, Anthony M. Slater, D.Huw Davies, Geoffrey A. Holdgate, Leslie R'. Green

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 1001 KB

english, 1994

15

The Entropic Penalty of Ordered Water Accounts for Weaker Binding of the Antibiotic Novobiocin to a Resistant Mutant of DNA Gyrase: A Thermodynamic and Crystallographic Study ‡

Holdgate, Geoffrey A., Tunnicliffe, Alan, Ward, Walter H. J., Weston, Simon A., Rosenbrock, Gina, Barth, Peter T., Taylor, Ian W. F., Pauptit, Richard A., Timms, David

Journal:

Year:

1997

Language:

english

File:

PDF, 488 KB

english, 1997

16

Biophysical methods in early drug discovery

Holdgate, Geoffrey, Embrey, Kevin, Milbradt, Alexander, Davies, Gareth

Journal:

Year:

2019

Language:

english

File:

PDF, 1021 KB

english, 2019

17

Elevated serum cytokines during human anaphylaxis: Identification of potential mediators of acute allergic reactions

Stone, Shelley F., Cotterell, Claire, Isbister, Geoffrey K., Holdgate, Anna, Brown, Simon G.A.

Journal:

Journal of Allergy and Clinical Immunology

Year:

2009

Language:

english

File:

PDF, 462 KB

english, 2009

18

Kinetic and Structural Characteristics of the Inhibition of Enoyl (Acyl Carrier Protein) Reductase by Triclosan ‡

Ward, Walter H. J., Holdgate, Geoffrey A., Rowsell, Siân, McLean, Estelle G., Pauptit, Richard A., Clayton, Edward, Nichols, Wright W., Colls, Jeremy G., Minshull, Claire A., Jude, David A., Mistry, A

Journal:

Year:

1999

Language:

english

File:

PDF, 229 KB

english, 1999

19

Kinetic efficiency: the missing metric for enhancing compound quality?

Geoffrey A. Holdgate, Adrian L. Gill

Journal:

Drug Discovery Today

Year:

2011

Language:

english

File:

PDF, 160 KB

english, 2011

20

Myc Phosphorylation in its Basic Helix-Loop-Helix Region Destabilizes Transient α-Helical Structures, Disrupting Max and DNA Binding

Macek, Pavel, Cliff, Matthew J, Embrey, Kevin J., Holdgate, Geoffrey A., Nissink, J. Willem M., Panova, Stanislava, Waltho, Jonathan P., Davies, Rick A.

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 1.29 MB

english, 2018

21

Measurements of binding thermodynamics in drug discovery

Geoffrey A. Holdgate, Walter H.J. Ward

Journal:

Drug Discovery Today

Year:

2005

Language:

english

File:

PDF, 168 KB

english, 2005

22

FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures

Klein, Tobias, Tucker, Julie, Holdgate, Geoffrey A., Norman, Richard A., Breeze, Alexander L.

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 3.96 MB

english, 2014

23

Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation

Ward, Richard A., Brassington, Claire, Breeze, Alexander L., Caputo, Alessandro, Critchlow, Susan, Davies, Gareth, Goodwin, Louise, Hassall, Giles, Greenwood, Ryan, Holdgate, Geoffrey A., Mrosek, Mich

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 3.39 MB

english, 2012

24

Methyl-Thiazoles: A Novel Mode of Inhibition with the Potential to Develop Novel Inhibitors Targeting InhA in Mycobacterium tuberculosis

Shirude, Pravin S., Madhavapeddi, Prashanti, Naik, Maruti, Murugan, Kannan, Shinde, Vikas, Nandishaiah, Radha, Bhat, Jyothi, Kumar, Anupriya, Hameed, Shahul, Holdgate, Geoffrey, Davies, Gareth, McMike

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.87 MB

english, 2013

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